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低氧細胞工作站
HypoxyLab?是一款結構緊湊，HEPA過濾，精密控制的低氧環境的工作站。
HypoxyLab為各種以細胞為基礎的研究領域創造適合的、無污染的低氧條件。
應用領域包括腫瘤生物學，放射細胞生物學，心血管研究，細胞凋亡，神經科學，干細胞研究，多學科的藥物開發和蛋白質組學。
真正的低氧復制
HypoxyLab?是調節培養環境中氧氣分壓的低氧工作站，從而提供盡可能高精度的真正的低氧培養。眾所周知，氧氣對細胞的有效性是“看”氧分壓的值。氧分壓不僅隨著氧氣濃度的變化而改變，而且還與海拔和天氣相關。 HypoxyLab是真正的革命性產品，它直接調節工作站內氧氣分壓的來提供低氧環境。我們用傳感器來測量氧氣而不補償濃度百分比來就可以表示低氧。
HypoxyLab以mmHg或kPa為單位表達工作站內的氧環境，而對變化的氣候和海拔條件不敏感。這一優越的科學方法使得HypoxyLab的準確性增強，相比其他的設備高出30％以上，這依賴于我們獨特的其他補償技術。由此，無論您的實驗室位于世界何地，都能夠確保提供精確的低氧環境。
測量的金標準
對于那些要求原位氧測量“金標準”到細胞生長的精確位置或所在層，HypoxyLab提供了一個可選的內置 OxyLite? 模塊來直接實時的進行細胞培養介質中的溶解氧測量。HypoxyLab具有工作站專用OxyLite傳感器連接器。當連接一個OxyLite 探頭，定位在培養基中，其溶解氧精確濃度值會自動地顯示在HypoxyLab的觸摸屏上并記錄在存儲卡中，顯示屏同時顯示的還有工作站的氧氣分壓，二氧化碳，溫度和濕度。可以方便地把這些數據以LabChart?兼容格式記錄到到USB閃存盤中，可用來做進一步的離線分析.
產品特性
- 真正的低氧復制
- 直接從細胞培養基中檢測氧氣
- 污染可控制的環境
- 無與倫比的精度
- 輕便的上蓋
- 簡潔大方的臺式外觀設計
- 規范采用氧分壓來衡量真正的低氧模擬在體氧環境
- 快速到達指定的低氧環境以及極底的氣體消耗
- HEPA過濾標準，可隨意更換，操作簡易
- 符合人體工程學設計
- 直觀便捷的觸摸屏
- 可選模塊 OxyLite? 可檢測培養液內部任意點位的溶解氧
- 可選微型電子顯微鏡
產品參數
(Updated: June 2021)
Rapid Evaluation of Novel Therapeutic Strategies Using a 3D Collagen-Based Tissue-Like Model. Maury P, Porcel E, Mau A, Lux F, Tillement O, Mahou P, Schanne-Klein MC, and Lacombe S (2021).?Front Bioeng Biotechnol. 2021 Feb 16;9:574035. doi: 10.3389/fbioe.2021.574035. eCollection 2021
Differentiated cells in prolonged hypoxia produce highly infectious native-like hepatitis C virus particles (2021). Cochard J, Bull-Maurer A, Tauber C, Burlaud-Gaillard J, Mazurier F, Meunier J-C, Roingeard P and Chouteau P.?Hepatology. 2021 Mar 4. doi: 10.1002/hep.31788. Online ahead of print
Impact of the acidic environment on gene expression and functional parameters of tumors in vitro and in vivo (2021). Rauschner M, Lange L, Hüsing T, Reime S, Nolze A, Maschek M, Thews O & Riemann A.
SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury (2020). Lu B, et. al.
Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer (2020). Malier M, Court M, Gharzeddine K, Laverierre M-H, Marsili S, Thomas F, Decaens T, Roth G & Millet A.
Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts (2020). Kozlov AM, Lone A, Betts DH & Cumming RC.?Nature Scientific Reports 10, 8388
Hypercapnia potentiates HIF-1α activation in the brain of rats exposed to intermittent hypoxia (2020). Tregubab PP, Malinovskayaa NA, Morguna AV, Osipovaa ED, Kulikovb VP, Kuzovkova DA, and Kovzelevc PD.?J. Resp 278, 103442
Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth…. (2019). Riemann A, Güttler A, Haupt V, Wichmann H, Reime S, Bache M, Vordermark D and Thews O.phage Polarization Under a Low Oxygen Environment (2019). Court M, Malier M and Millet A.
The effect of hypoxia on ZEB1 expression in a mimetic system of the blood-brain barrier (2018). Leduc-Galindo D, Qvist P, Tóth AE, Fryland T, Nielsen MS, B?rglum AD and Christensen JH.
Acidic extracellular environment affects miRNA expression in tumors in vitro and in vivo (2018). Riemann A, Reime S, and Thews O.
Induction and Assessment of Hypoxia in Glioblastoma Cells In Vitro (2018). Gagner JP, Lechpammer M and Zagzag D
Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo (2017). Riemann A, Reime S and Thews O.
Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1 (2017). Kulkarni A, Mateus M, Thinnes CC, McCullagh JS, Schofield CJ, Taylor GP and Bangham CRM.
